Other Meta Analysis

In Search of the Fountain of Youth -- Preliminary Analysis of Deuterium’s Role in DNA Degradation

https://www.researchgate.net/profile/Patrice_Westbrook2/publication/13719105_In_search_of_the_fountain_of_youth/links/58263ab208aecfd7b8be8615.pdf

 

Research progress of biological effects of deuterium-depleted water

http://202.120.143.160/EN/abstract/abstract11903.shtml

 

Determination of Biological Activity of Water Having a Different Isotope Ratio of Protium and Deuterium

https://link.springer.com/article/10.3103/S1063455X18010058

 

Biological effects of deuterium - depleted water

https://inis.iaea.org/search/search.aspx?orig_q=RN:33051577

 

The Isotopic Effects of Deuterium on Biological Objects

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1031.2239&rep=rep1&type=pdf

 

Influence of deuterium-depleted water on living organisms

https://www.osti.gov/etdeweb/biblio/20147441

 

A Cure for Some Cancers?

Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro

https://www.sciencedirect.com/science/article/abs/pii/S0753332213000176

 

Biological significance of naturally occurring deuterium: the antitumor effect of deuterium depletion

https://akjournals.com/view/journals/650/151/36/article-p1455.xml

 

Anticancer Effect of Deuterium Depleted Water - Redox Disbalance Leads to Oxidative Stress

https://www.mcponline.org/content/18/12/2373.abstract

 

Study of the deuterium depletion water in the cancer medical treatment in Japan

https://www.osti.gov/etdeweb/biblio/20573538

 

Pre-Clinical and Clinical Data Confirm the Anticancer Effect of Deuterium Depletion

http://www.bmmj.org/&url=http://www.bmmj.org/article_21156.html

 

Deuterium Depletion May Delay the Progression of Prostate Cancer

http://oncology.lightwater.com/15.Journal%20of%20Cancer%20Therapy%202011.pdf

 

Deuterium Depleted Water Inhibits the Proliferation of Human MCF7 Breast Cancer Cell Lines by Inducing Cell Cycle Arrest

https://www.tandfonline.com/doi/abs/10.1080/01635581.2019.1595048

 

Deuterium Depleted Water Effects on Survival of Lung Cancer Patients and Expression of Kras, Bcl2, and Myc Genes in Mouse Lung

https://www.tandfonline.com/doi/full/10.1080/01635581.2013.756533

 

Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis

https://www.spandidos-publications.com/10.3892/etm_00000043

 

Immune System Improvements

Radioprotective and Immunostimulating Effects of Deuterium-Depleted Water

"Auxiliary tests using chemical radiomimetics (hydrochloric embihine) and immunosupressors (cyclophosphamide) showed a strong protective effect of deuterium-depleted water against the decrease of the leukocyte counts and other immunologic parameters. In conditions of experimental inflammation with subcutaneous-implanted pellets, deuterium-depleted water feeding statistically significant increased inflammatory response, obviated by increased percentages of PMN and lymphocytes in the peripheral blood and increased phagocytic capacity of the peripheral blood PMN. Experimental infections with K. pneumoniae 506 and S. pneumoniae 558 in mice irradiated or treated with cyclophosphamide showed increased non-specific immunity parameters. All results show a marked intensification of the immune defenses and increased proliferation of the peripheral blood cells, probably accounting for the radioprotective effects."

https://www.osti.gov/etdeweb/biblio/20260757

 

Biological effects of deuterium - depleted water

"Animals treated with DDW showed an increase of the resistance both to sublethal and lethal gamma radiation doses, suggesting a radioprotective action by the stimulation of non-specific immune defense mechanisms; - DDW stimulates immuno-defense reactions represented by the opsonic, bactericidal and phagocyte capacity of the immune system together with an increase in the number of poly-morphonuclear neutrophils; - Investigations regarding artificial reproduction of fish with DDW fecundated solutions confirmed favorable influence in embryo growth stage and resistance and following growth stages; - It was studied germination, growth and quantitative character variability in plants; one can remark the favorable influence of DDW on biological processes in plants in various ontogenetic stages."

https://inis.iaea.org/search/searchsinglerecord.aspx?recordsFor=SingleRecord&RN=33051577

 

The effect of the deuterium depleted water on the biological activity of the eukaryotic cells

https://www.sciencedirect.com/science/article/abs/pii/S0946672X17307964

 

Effect of Deuterium-Depleted Water on Immunomodulation in Mice

http://en.cnki.com.cn/Article_en/CJFDTotal-AJSH201003018.htm

 

Deuterium - depleted water. Achievements and perspectives

"Deuterium - depleted water stimulates immune defence reactions, represented by the opsonic, bactericidal and phagocyte capacity of the immune system, together with increase in the numbers of polymorphonuclear neutrophils;"

https://inis.iaea.org/search/search.aspx?orig_q=RN:32044732

 

The effects of deuterium-depleted water on bacteria

https://www.osti.gov/etdeweb/biblio/20240488

 

Radioprotection by pretreatment with deuterated water: cytokinetic changes in the small intestine of the mouse

https://link.springer.com/content/pdf/10.1007/BF02899214.pdf

 

THE RADIOPROTECTIVE EFFECT OF DEUTERIUM DEPLETED WATER AND POLYPHENOLS

"The DDW presence in the time of X-irradiation of the animals, reduce significantly the injuries produced by X-irradiation at the liver level, the ultrastructural features being appropriate to Control animals; - the X-irradiation of the animals in the presence of DDW and a total polyphenols extract from cortex of Aralia mandshurica, manifest a strong stressprotector effect;"

https://www.researchgate.net/profile/Corneanu_Mihaela2/publication/283010706_The_radioprotective_effect_of_deuterium_depleted_water_and_polyphenols/links/56262f6208aeedae57dbc2b1.pdf

 

Improvements in Cognition and Stress Level

Deuterium-depleted water has stimulating effects on long-term memory in rats

https://www.sciencedirect.com/science/article/abs/pii/S0304394014007745

 

Relation of antistress and geroprotective effects of deuterium depleted water in aging female rats

https://pdfs.semanticscholar.org/d188/282b624de17d12dba71a9ac56235f7e59765.pdf

 

Deuterium depletion induces anxiolytic-like effects in rats

http://www.doiserbia.nb.rs/Article.aspx?ID=0354-46641402947M

 

Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism.

"Geographical distribution of deuterium correlates with depression rate."

"Deuterium depleted water reduces stress-induced depressive-like signs in mice."

"Finally, in naïve mice, deuterium-depleted water treatment increased EEG indices of wakefulness, and decreased duration of REM sleep, phenomena that have been shown to result from the administration of selective serotonin reuptake inhibitors (SSRI). Our data suggest that the deuterium content of water may influence the incidence of affective disorder-related pathophysiology and major depression, which might be mediated by the serotoninergic mechanisms."

https://www.sciencedirect.com/science/article/pii/S0166432814004884

 

Genetic Stabilization and Aging Prevention

Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model

https://www.sciencedirect.com/science/article/abs/pii/S0378427412009526

 

On the possibility of observing kinetic isotopic effects in the life cycles of living organisms at ultralow concentrations of deuterium

https://link.springer.com/article/10.1134/S1019331615020057

 

Deuterium-Depleted Water Influence on the Isotope 2H/1H Regulation in Body and Individual Adaptation

"We found the 2H/1H gradient in human fluids (δ2H saliva >> δ2H blood plasma > δ2Hbreast milk), which decreases significantly during DDW intake. Moreover, DDW induces several important biological effects in organism (antioxidant, metabolic detoxification, anticancer, rejuvenation, behavior, etc.). Changing the isotope 2H/1H gradient from “2H blood plasma > δ2H visceral organs” to “δ2H blood plasma << δ2H visceral organs” via DDW drinking increases individual adaptation by isotopic shock. The other possible mechanisms of long-term adaptation is DDW influence on the growth rate of cells, enzyme activity and cellular energetics (e.g., stimulation of the mitochondrion activity). In addition, DDW reduces the number of single-stranded DNA breaks and modifies the miRNA profile."

https://www.mdpi.com/2072-6643/11/8/1903

 

Estimation of the influence of medium with different isotopic D/H composition on DNA lymphocytes repair

"According to the experiment it was found that incubation in solution with deuterium depleted water of lymphocytes obtained from the blood of the patients with congenital malformations of the maxillofacial area, reduces the number of single-strand DNA breaks by 21–24 %. It has been shown that incubation of lymphocytes in solutions with deuterium depleted water activates DNA repaire system."

https://medvestnik.stgmu.ru/en/articles/324-Estimation_of_the_influence_of_medium_with_different_isotopic_D_H_composition_on_DNA_lymphocytes_repair.html

 

Neuroprotective Effects of Deuterium-Depleted Water (DDW) Against H2O2-Induced Oxidative Stress in Differentiated PC12 Cells Through the PI3K/Akt Signaling Pathway

https://link.springer.com/article/10.1007%2Fs11064-020-02978-4

 

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle

https://www.sciencedirect.com/science/article/pii/S0306987715004399

 

The effects of environmental deuterium on normal and neoplastic cultured cell development

https://www.osti.gov/etdeweb/biblio/20240485

 

Anti-inflammatory Properties

Anti-inflammatory Effects of Deuterium-Depleted Water Plus Rosa Damascena Mill. Essential Oil Via Cyclooxygenase-2 Pathway in Rats

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227869/

 

Deuterium depletion effects in rats with experimentally induced chronic inflammation

https://inis.iaea.org/search/search.aspx?orig_q=RN:39071489

 

Health and Wellness

Deuterium-Depleted Water as Adjuvant Therapeutic Agent for Treatment of Diet-Induced Obesity in Rats

https://www.mdpi.com/1420-3049/25/1/23

 

Studying the Influence of Heavy and Deuterium Depleted Types of Water on Biological Objects

"The positive influence of drinking deuterium depleted water on blood chemistry included a significant
reduction of glucose, cholesterol, erythrocyte sedimentation rates, leukocyte counts and cortisol (stress hormone) levels, while also revealed an increase in antioxidant capacities [Andreeva et al., 2005; Burdeynaya et al., 2012; Olariu et al., 2010). These data evidence the significance of deuterium depleted water to increase energy resources even in a healthy cohort, while decreasing risks of psycho-emotional stress, which is known to pose a negative influence on blood biochemistries that often lead to psychosomatic diseases and shorten life."

http://www.medicalbiophysics.bg/en/29212.html

 

It's also good for plants

The deuterium depleted water effects on germination, growth and respiration processes in Zea Mays culture

https://www.osti.gov/etdeweb/biblio/20333924

 

Influence of deuterium depleted water upon plant organisms

https://inis.iaea.org/search/search.aspx?orig_q=RN:34021795